Patient Drug Information & Medication Resource Guide
SemaMelt Plus No Caffeine
SemaMelt Plus is a compounded oral dissolvable tablet (ODT) designed to tackle appetite and cravings from multiple angles.
Formulation
Tablet Description
Impressions may vary depending on dosages.

Mint Flavor, White
Semaglutide 2.75mg + Naltrexone HCL 3mg

Mint Flavor, Green
Semaglutide 5mg + Naltrexone HCL 5mg
How Does It Work
This unique combination targets appetite control through hormonal, neurological, and metabolic mechanisms:
- Semaglutide: A GLP-1 receptor agonist that promotes fullness, slows gastric emptying, and reduces food cravings. It helps regulate insulin and glucose, supporting long-term fat loss and metabolic stability.
- Naltrexone: A low dose opioid receptor modulator that reduces reward-driven eating behaviors and emotional cravings. When used in weight loss, it supports appetite reduction and may improve adherence to dietary goals.
Benefits of SemaMelt Plus
- Reduces Appetite and Emotional Cravings
- Enhances Satiety and Glucose Control
- Non-injectable, Fast-Dissolving, and Easy to Use
Directions for Use
Place one ODT under the tongue and allow it to fully dissolve. Best taken in the morning or as directed by your healthcare provider. Avoid food or drink for at least 30 minutes after dosing to maximize efficacy.
Potential Side Effects
- Semaglutide: Nausea, constipation, or bloating
- Naltrexone: Headache or mild GI discomfort
Who Should Not Use SemaMelt Plus
- Individuals with a personal or family history of medullary thyroid carcinoma (MTC)
- Patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)
- Those taking opioid medications or with opioid dependence
- Pregnant or breastfeeding individuals
How do I store and/or dispose of this drug?
Store at room temperature. Protect from light. Avoid exposure to high humidity (keep container tightly closed). Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain. Check with your pharmacist if you have questions about how to throw out drugs. Do not share your drugs with others and do not take anyone else’s drugs. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-888-463-6332 or at https://www.fda.gov/medwatch.
Exclusively Made By EPIQ SCRIPTS
Epiq Scripts is a URAC- and ACHC/PCAB-accredited compounding pharmacy, committed to the highest standards of safety, quality, and regulatory compliance. All ingredients are sourced exclusively from FDA-registered and inspected wholesalers to ensure pharmaceutical-grade purity and efficacy. Our compounds are crafted with precision in a state-of-the-art facility adhering to strict USP guidelines.
Compounded Medication Disclaimer
This is a custom-compounded medication prepared by a licensed pharmacy for individual patient use. It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider.
Compounded medications are made in accordance with Section 503A of the Federal Food, Drug, and Cosmetic Act, and are intended to address unique patient needs when FDA-approved options are not appropriate or available.