Patient Drug Information & Medication Resource Guide

SemaTirze Melt

This is a special formulation containing both semaglutide and tirzepatide as dual incretin-acting pathway agonists working on GIP and GLP-1 receptors to support metabolic health and chronic weight management.

Formulation

Product Description

Individual response varies based on baseline physiology, dosing/titration, adherence, and concurrent lifestyle interventions.

SemaTirze Melt light red tablet

Strawberry Flavor, Light Red

Semaglutide 12mg + Tirzepatide 10mg

Semaglutide 12mg; Tirzepatide 10mg: 10mm light red, round convex tablet with Epiq logo imprint on one side, strawberry flavored.

SemaTirze Melt light yellow tablet

Banana Flavor, Light Yellow

Semaglutide 24mg + Tirzepatide 20mg

Semaglutide 24mg; Tirzepatide 20mg: 10mm light yellow, round convex tablet with Epiq logo imprint on one side, banana flavored.

Alert

DO NOT TAKE this product if you or your family have had medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

How Does It Work

This formulation combines two incretin-based therapies intended to support metabolic signaling pathways involved in glucose regulation and appetite control.

  • Semaglutide is a GLP-1 receptor agonist. Activation of GLP-1 receptors is associated with glucose-dependent insulin secretion, reduced glucagon release, delayed gastric emptying, and appetite regulation.
  • Tirzepatide is a dual GIP and GLP-1 receptor agonist. Activation of these pathways is associated with enhanced insulin secretion, glucagon modulation, and satiety signaling.
Important: Clinical evidence for semaglutide and tirzepatide is derived from FDA-approved injectable and oral tablet formulations. Clinical equivalence of compounded oral dissolvable tablet formats has not been established.

Potential Clinical Benefits

  • Supports metabolic signaling pathways involved in appetite and glycemic regulation
  • May support weight management efforts under medical supervision
  • Provides dual incretin receptor pathway engagement

Directions for Use

Use only as prescribed by your healthcare provider. Allow the tablet to fully dissolve as directed. Dosing and titration should be individualized based on clinical response and tolerability. Clinical monitoring may include weight trends, glycemic metrics (as applicable), blood pressure, and symptom response.

Potential Side Effects

  • Nausea
  • Vomiting
  • Diarrhea or constipation
  • Abdominal discomfort
  • Decreased appetite
  • Fatigue
  • Hypoglycemia risk increases when used with insulin or insulin secretagogues
Patients should contact their clinician for persistent severe GI symptoms or signs of dehydration.

Who Should Not Use SemaTirze Melt

  • Individuals with known hypersensitivity to any component
  • Patients with personal or family history of medullary thyroid carcinoma (MTC) or MEN2
  • Pregnant or breastfeeding individuals unless directed by a clinician
  • Patients with a history of pancreatitis should be evaluated carefully prior to use

How do I store and/or dispose of this drug?

Store at room temperature. Protect from light. Avoid exposure to high humidity (keep container tightly closed). Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain. Check with your pharmacist if you have questions about how to throw out drugs. Do not share your drugs with others and do not take anyone else’s drugs. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-888-463-6332 or at https://www.fda.gov/medwatch.

Exclusively Made By EPIQ SCRIPTS

Epiq Scripts is a URAC- and ACHC/PCAB-accredited compounding pharmacy, committed to the highest standards of safety, quality, and regulatory compliance. All ingredients are sourced exclusively from FDA-registered and inspected wholesalers to ensure pharmaceutical-grade purity and efficacy. Our compounds are crafted with precision in a state-of-the-art facility adhering to strict USP guidelines.